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Biochemical Signals Identified That Help Immune Cells Remember How To Fight Infection
Immunology researchers at UT Southwestern Medical Center have discovered how two biochemical signals play unique roles in promoting the development of a group of immune cells employed as tactical assassins.
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New Study Shows Nplate(R) Significantly Reduces Splenectomy Rate And Treatment Failure In Patients With Chronic ITP
Amgen Inc. (Nasdaq: AMGN) today released the results of a new study comparing Nplate(R) (romiplostim) to the medical standard of care (SOC) in non-splenectomised adult patients with chronic immune thrombocytopenic purpura (ITP). Chronic ITP is a serious autoimmune disorder characterised by low platelet counts in the blood (thrombocytopenia), which can lead to serious bleeding events. The study results show Nplate significantly reduced the incidences of splenectomy and treatment failures in non-splenectomised adult patients with chronic ITP when compared to medical SOC. The results were presented today as an oral presentation at the 14th congress of the European Hematology Association (EHA abstract #1672).
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Obama Plan To Cut Hospital Payments Draws Ire
The Obama administration has called for $200 billion in cuts for hospital reimbursements in an effort to overhaul the health care system. Federal funding under the reimbursement system known as "disproportionate share payments" is provided to hospitals in large part to help meet the cost of caring for the uninsured. Administration officials argue that as the number of uninsured decrease, reimbursements should also fall. However, hospital leaders and staff worry about such cuts as well as calls for a government-run insurance plan to compete with private plans.
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1957-58 Flu Pandemic Can Provide Clues To Planning For H1N1

As the U.S. prepares for a resurgence of H1N1 influenza this fall, much can be learned from looking at a previous pandemic that had similar patterns. In an article published today in Biosecurity and Bioterrorism, researchers at the Center for Biosecurity of the University of Pittsburgh Medical Center (UPMC) examined historical documents, published material, and newspaper coverage related to the 1957-58 influenza pandemic to compare the progress and severity of that outbreak with the current one. The simple, practical actions taken in 1957 allowed the country to continue functioning with minimal disruption. Lead author Dr. D. A. Henderson had major responsibility for establishing the CDC influenza surveillance program during the early stages of the 1957 flu; data and analysis of events presented are based on his direct experiences as well as copies of surveillance reports that were published in 1957-58. "There is need for an understanding in national policy circles of the options for dealing with a pandemic, and time is short if states and local communities are going to be prepared," said Henderson. During the 1957 pandemic, 25% of the U.S. population became ill, and excess mortality due to pneumonia and influenza occurred. It was a rapidly spreading disease, and it quickly became apparent to U.S. health officials that efforts to stop or slow its spread were futile. Thus, no efforts were made to quarantine individuals or groups, and a deliberate decision was made not to cancel or postpone large meetings such as conferences, church gatherings, or athletic events. Health officials emphasized providing medical care to those who were sick and keeping community and health services functioning. School absenteeism was high, but schools were not closed unless the number of students or teachers fell low enough to warrant closure. Special efforts were made to speed the production of vaccine, but the quantities that were produced were too late to substantially affect the impact of the epidemic. The spread of the disease was so rapid that within 3 months it had swept across the country and had largely disappeared. Although it is impossible to predict the course that H1N1 will take, planning for it can be informed by the experiences of the recent past. Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science, a quarterly peer-reviewed journal, is published by Mary Ann Liebert, Inc.. The Center for Biosecurity is an independent, nonprofit organization of the University of Pittsburgh Medical Center (UPMC) whose mission is to strengthen national security by reducing the risks posed by biological attacks, epidemics, and other destabilizing events, and to improve the nation"s resilience in the face of such events.. Center for Biosecurity of UPMC


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