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Whistleblower Case Against Healthways, Inc. Settled For $40,000,000
A 15-year whistleblower case filed by a former employee against Healthways, Inc. has been settled for approximately $40,000,000 in damages and fees. The case was initiated in June 1994, when A. Scott Pogue, who had recently been fired from his job as a marketing representative for a company called Diabetes Treatment Centers of America, filed a case in Nashville under the United States Civil False Claims Act against his former employer.
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DACH1 A Key Protein For Tumor Suppression In ER+ Breast Cancer
Researchers from the Kimmel Cancer Center at Jefferson have identified a protein relationship that may be an ideal treatment target for ER+ breast cancer. The study was reported in the July 15 issue of Cancer Research.
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MS Society Appoints New Director
The MS Society has appointed Sue Farrington to its newly created role of Director of Information and Education. Sue was formerly Director of Corporate Affairs at CSV.
Sexual Health

Breast Cancer Etiology May Vary By Subtype

Women"s reproductive and lifestyle characteristics can be linked to different invasive breast cancer subtypes. Data on 2544 breast cancer cases, presented in the open access journal Breast Cancer Research, suggests that traditional risk factors for development of the condition are associated with different kinds of tumor. Marilyn Kwan from Kaiser Permanente Division of Research, California, led a team of researchers who used data from the LACE (Life After Cancer Epidemiology) and Pathways studies to investigate the characteristics of women with different breast cancer subtypes: luminal A, luminal B, triple negative and Her2-overexpressing. She said, "These varying associations by subtype lend further support to the growing evidence base that breast cancer is a heterogeneous disease defined by estrogen receptor, progesterone receptor, and Her2 expression with distinct etiologic pathways and prognoses". The researchers found that patients with luminal B tumors were generally younger at diagnosis than those with luminal A and were less likely to consume alcohol, use HRT or use oral contraceptives. Compared to luminal A cases, triple negative cases tended to be African American, younger at diagnosis and overweight/obese if premenopausal. Her2-overexpressing cases were also more likely to be seen in younger patients than luminal A cases and were more likely to be Hispanic or Asian. Kwan concludes, "Future research should focus on refinement of tumor subtypes in order to best elucidate how the risk factors may vary. Important modifiable factors that may be related to the development of specific tumor subtypes include obesity in the case of triple negative cancers and alcohol consumption for luminal B tumors". Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors Marilyn L Kwan, Lawrence H Kushi, Erin Weltzien, Benjamin Maring, Susan E Kutner, Regan S Fulton, Marion M Lee, Christine B Ambrosone and Bette J Caan Breast Cancer Research (in press) http://breast-cancer-research.com/ Graeme Baldwin BioMed Central


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