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Tobira Therapeutics Inc. Announces Phase I Data Demonstrating Pharmacokinetic Properties Of TAK-652 For The Treatment Of HIV
Tobira Therapeutics Inc., a clinical stage biotechnology company committed to research and product discovery for the treatment of life-threatening and life-altering infectious diseases, today announced pharmacokinetic data and results from two Phase I pharmacokinetic studies for TAK-652, an investigational compound being developed for the treatment of HIV. These data suggest that TAK-652 is rapidly absorbed and demonstrate relatively good oral bioavailability (as shown by the plasma TBR-652 concentration data) and has a long plasma half-life of TBR-652 (approximate mean of 35 hours) supporting once-daily dosing. Mean TBR-652 plasma concentrations were well above the predicted target plasma concentration (2ng/mL) with or without food. In both studies TBR-652 was safe and well tolerated in this healthy subject population when administered over a dose range of 10 mg to 800 mg in 2 tablet formulations. "These two Phase I studies provide encouraging support for TAK-652 as a therapeutic option for the treatment of HIV. We look forward to results from our on-going proof-of-concept study," said James Sapirstein, CEO.
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Health Insurance Exchanges Gain Attention
Kaiser Health News reports on health insurance exchanges, a concept now being considered in the context of Congress"s health overhaul proposals. "The seemingly simple idea behind exchanges - one-stop shopping for insurance - masks the cornerstone role they may play in a national overhaul of the health system. President Obama supports the idea, and exchanges are included in most of the health care proposals now before Congress. Done right, proponents say, exchanges could transform how insurance is sold, giving individuals and small businesses improved purchasing power, increasing price competition among insurers and creating standardized benefits. Done poorly, analysts and critics say, exchanges could drive up insurance costs and encourage employers to drop coverage, unraveling the system that insures most working Americans. While it"s still unclear what Congress will do, Senate Democrats have looked closely at Massachusetts. Here"s how it works there: The state established its exchange, called the Health Connector, mainly for the benefit of individuals who aren"t insured by employers. They include the self-employed and the unemployed, two categories of people who traditionally have the most difficulty obtaining policies. Although not required to buy through the exchange, doing so gives them group-purchasing power. Lower-income people are eligible for state subsidies."
News of the day
Thirteen Single-Payer Activists Settle Their Cases After Disrupting Hearing
Thirteen people charged with "disruption of Congress" for standing and shouting pro-single-payer system slogans during a health care reform committee hearing settled their cases, The Great Falls (Mont.) Tribune reports.
Sexual Health

Innovative Hand Dryer Pilot To Help Combat HCAIs, UK

An innovative hand dryer aimed at cutting the risk of healthcare associated infections (HCAIs) has been launched for NHS trusts and healthcare organisations by NHS Supply Chain. NHS Supply Chain is running a pilot contract across the country for Dyson Airblade™ - the only hand dryer certified by the leading public health and safety company, NSF International.* The Dyson Airblade™ is the fastest and most efficient hand dryer. It dries hands up to four times quicker than standard hand dryers by scraping water off hands with a jet of air travelling at 400 mph, and eliminates 99.9% of bacteria from the air used to dry hands with a HEPA filter. "This truly is an innovation," said Chris Graham, Senior Buyer at NHS Supply Chain. "Wet hands harbour up to 1000 times more bacteria than dry hands and in turn spread infection across healthcare sites. Patients and healthcare workers are able to dry their hands within ten seconds and at a fraction of the cost." When compared with standard hand drying methods, each Dyson Airblade™ hand dryer can save NHS trusts up to ÷£2,000 a year in operating costs. "The Airblade has been introduced on a trial basis in response to customer interest," said Chris. "It is a welcome addition to our range of products aimed at helping NHS customers combat the threat of HCAIs." NHS Supply Chain


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