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Novel Compounds May Help Protect Against Respiratory Depression
A paper that appears in the June 2009 issue of Anesthesiology details how AMPAKINE CX717, a Phase II compound created by Irvine, California-based neuroscience company Cortex Pharmaceuticals, demonstrated the rescue of fentanyl-induced respiratory depression and sleep apnea in rats. In this same study, CX717 demonstrated equal efficacy with the opioid antagonist Naloxone, a drug used to counter the effects of opioids on suppression of breathing. CX717 did not, however, interfere with the action of pain-killing opiates. This offers a distinct advantage compared with Naloxone and could provide a novel therapeutic means of treating those patients who are particularly prone to breathing depression with opiates while achieving maximum pain relief.
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Disability Awareness Day 2009 Sunday 12th July
"Absolutely inspirational" that"s was the expression used by one visitor to describe last years Northwest Disability Awareness Day (DAD).
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Action Needed To Realise The Potential Of New Genetic Studies
New studies that analyse genetic differences across thousands of human genomes
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Loneliness Among Older People, Study

Professor Bo Malmberg and Professor Gerdt Sundstrē¶m at the School of Health Sciences in Jē¶nkē¶ping, Sweden have studied loneliness among older people. A common stereotype about older people is that loneliness is typical for older women, rather than for older men. One problem with this stereotype is that feelings of loneliness are not particularly common among either men or women in the Nordic countries. "Some studies show a lower prevalence among women and some a lower among men. We use several national and local surveys to analyze gender differences in perceived loneliness. Longitudinal surveys, which enable us to analyze changes during ageing,", says Bo Malmberg and Gerdt Sundstrē¶m Older people who still live at home in communities in Scandinavian welfare states are either married or living alone, with the latter group reporting more of a sense of loneliness. Two mar÷­riages out of three end in the death of the husband, and if marital status is excluded from the equation, most of the differences in loneliness between the genders disappear. Yet, in the 80+ age group, (the few) men who live alone report a higher frequency of loneliness than women in the same category. At that age, most men are still married, but most women are living alone. These patterns are even more pronounced in the 90+ age group. "We interpret the results as the outcome of selection mechanisms and that they may reflect male-female differences in marital adaptation. Those men who survive and live alone are more often from a working-class background and in poor health, while women who live alone are socially and health-wise a more heterogeneous group", says Bo Malmberg and Gerdt Sundstrē¶m. There may also be a difference in marital back÷­ground, colouring the way men and women see their situation: men more often have had their wives as their only confidant, whereas women have a wider social network and may even see their new solitary life as a relief. Vetenskapsradet


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