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Bulging British Men Want A Slice Of Their Wives' Weight-Loss Pie, UK
This country is at war with obesity and now men join their women in the fight, says Exante Diet.
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Achaogen Data Show Rapid Rise In Rates Of Resistance To Current Antibiotics
Achaogen, a clinical stage biopharmaceutical company addressing the issue of multi-drug resistant bacterial infections through the discovery and development of innovative broad-spectrum antibiotics, announced today the presentation of research on aminoglycoside (AG) resistance trends and comparative AG toxicities at the 19th Annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), being held May 16-19, 2009 in Helsinki, Finland.
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Pregnant Women With H1n1 Flu Should Start Antiviral Treatment As Soon As Possible, While Those Who Are Well Should Be Vaccinated
An Article published Online First (http://www.thelancet.com) and in an upcoming edition of The Lancet shows that pregnant women could be at increased risk for complications from H1N1 flu. Furthermore, the study, from the USA, shows that the rate of hospitalisation for pregnant women is more than four times that of the general population. Pregnant women with H1N1 flu should start antiviral treatment as soon as possible, while those who are well should be vaccinated once a vaccine becomes available. The Article is written by Dr Denise J Jamieson, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA, and colleagues.
Medical Devices

MiR-196a Promotes The Metastases Of Tumors

MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. High levels of miR-196a, a microRNA suppressing the expression of specific homebox genes that are of high relevance for the development of the human embryo, activated oncogenic pathways inside human tumor cells and induced tumor cell dissemination. miR-196a increased the chemosensitivity towards platin derivatives such as cisplatin and oxaliplatin and might be a useful biomarker. Analysing the microRNA expression pattern in pancreatic cancer by microRNA chip analyses, Carlo Croce found that 75% of tumours expressed miR-196a at a high level, predicting poor patient survival. Yekta and colleagues first described a miR-196a-directed cleavage of specific homebox genes (HoxB8, HoxC8, HoxD8 and HoxA7) in mouse embryos and mammalian cells. As a tumour-suppressive effect of HoxC8 has been previously discussed in humans, it has been hypothesized that miR-196a might promote tumour progression. A research article published on May 7, 2009 in the World Journal of Gastroenterology addresses this question. In fact, Carl Schimanski and colleagues report that miR-196a supports tumour cell detachment and tumour cell dissemination in vitro via activation of the AKT pathway. In order to confirm these experiments, they performed animal studies with immune suppressed mice which received a tail vein injection of human tumour cells. Pretreatment of tumour cells with miR-196a lead to significantly more lung metastases in these animals. Therefore, the authors conclude that miR-196a does support the development of metastases by exerting a pro-oncogenic function. Noteworthy, several other microRNA have been described that exert pro-oncogenic funtions, such as miR-17-92 which is significantly increased in small-cell lung cancer and decreases survival by inhibition of tumour-suppressor genes PTEN and RB2. The exact mode of function of miR-196a still needs to be analysed. Reference: Schimanski CC, Frerichs K, Rahman F, Berger M, Lang H, Galle PR, Moehler M, Gockel I. High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. World J Gastroenterol 2009; 15(17): 2089-2096 http://www.wjgnet.com/1007-9327/15/2089.asp Correspondence to: Carl Christoph Schimanski, First Department of Internal Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. Lin Tian World Journal of Gastroenterology


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