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Liver Transplantation After Drug Induced Acute Liver Failure Examined By Study
Liver transplantation offers a good chance for survival for patients with drug induced acute liver failure, however, certain pre-transplant factors are associated with worse outcomes. Patients who are on life support, who have elevated serum creatinine, and children whose liver failure was caused by antiepileptic drugs did not fare as well after transplantation. These findings are in the July issue of Liver Transplantation, a journal published by John Wiley & Sons. The article is also available online at Wiley Interscience.
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Boston Arm Of Multi-City Study To Focus On Sexual Health, HIV Risk Among Black Gay, Bisexual Men
Boston-based Fenway Health and the Multicultural AIDS Coalition "have launched the recruitment phase of a new study aimed at learning more about the sexual health of black gay and bi[sexual] men and finding effective strategies for HIV prevention within the black gay community," Bay Windows reports. The study, called Project Saving Ourselves (SOS), is seeking to recruit up to 400 participants in Boston, and also is collecting data on black gay and bisexual men in New York, Washington, D.C., Atlanta, Los Angeles and San Francisco. Ben Perkins, Project SOS director at the Fenway Institute of Fenway Health"s research division, said, "This is pretty new. In terms of the scale, there hasn"t been anything quite like it." Perkins said there are several questions researchers hope to answer about black gay and bisexual male health and HIV prevention, but the goal is to determine what factors put them at risk for HIV and help promote better health and safe behavior (Jacobs, 7/15).
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Elagolix Successful In Six Month Lilac Petal Study; Safety And Efficacy Confirmed In Patients With Endometriosis
Neurocrine Biosciences, Inc. (Nasdaq: NBIX) announced new six month safety and efficacy results from its fourth Phase II clinical trial using its proprietary, orally-active non-peptide Gonadotropin-Releasing Hormone (GnRH) receptor antagonist, elagolix, in patients with endometriosis. Consistent with previously reported six month (Petal Study) and three month (Lilac Petal Study) results, a favorable safety profile and clinically meaningful efficacy have again been confirmed through month six of the Lilac Petal Study. This newly available data also provides clinical confirmation of Neurocrine"s extensive pharmacologic modeling related to the elagolix dose-response continuum. The outcome of primary interest at month six was the impact of the elagolix 250 mg dose on bone mineral density (BMD) as measured by dual energy X-ray absorptiometry (DXA) scanning.
Medical Devices

Microbial Analysis, Micropatterning Methods Featured In Cold Spring Harbor Protocols

Microbial populations have traditionally been studied in carefully controlled, laboratory-grown cultures. New metagenomic approaches are being developed to study these organisms in environmental or medical samples. The July issue of Cold Spring Harbor Protocols presents a method developed by Holger Daims from the University of Vienna for quantifying populations of microorganisms in a variety of naturally occurring conditions such as plankton samples or biofilms. Use of Fluorescence In Situ Hybridization and the daime Image Analysis Program for the Cultivation-Independent Quantification of Microorganisms in Environmental and Medical Samples combines fluorescent in situ hybridization using rRNA-targeted probes with digital image analysis. The results show an organism"s "biovolume fraction" in a given sample; this indicates the share of biochemical reaction space occupied by the quantified population and can be more relevant ecologically than absolute cell numbers. The article is freely available on the website for Cold Spring Harbor Protocols. Micropatterning methods are rapidly becoming standard approaches for investigating cellular behaviors such as growth and migration. Adhesive Micropatterns for Cells: A Microcontact Printing Protocol from Matthieu Piel and colleagues at the Institut Curie offers a simple, fast, and efficient method for generating micropatterns for cellular studies. Employing an elastomeric stamp to print proteins on the substrate of choice, this technique does not require much of the expensive equipment and technical expertise needed for most micropatterning methods, making it easier to implement in biology laboratories. The authors have provided a movie that illustrates the technique step-by-step as part of the protocol. The article is freely accessible on the website for Cold Spring Harbor Protocols. Cold Spring Harbor Protocols


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