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New Endograft Introduction System Enhances Physician Control During Minimally Invasive Treatment For Thoracic Aortic Aneurysms
In a development aimed at improving patient outcomes, physicians treating thoracic aortic aneurysms (TAA) will now experience a new level of control while placing endografts during thoracic endovascular repair procedures. With the launch of Cook Medical"s new Z-TRAK PLUS™ Introduction System, physicians are provided with improved maneuverability for controllable device orientation and deployment of the Zenith® TX2™ TAA Endovascular Stent Graft compared to earlier Cook delivery systems.
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Fighting Tuberculosis With Anti-inflammatory Drugs Shown Possible In Animal Studies
Tuberculosis (TB) experts at Johns Hopkins have evidence from a four-year series of experiments in mice that anti-inflammatory drugs could eventually prove effective in treating the highly contagious lung disease, adding to current antibiotic therapies.
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All Together Now - Primary Care's Role In A Tough Economic Climate
The financial crisis and lack of trust in public services mean that the NHS and the government face tough political and economic challenges ahead. In this climate, improvements in health services will only be possible if primary care takes the lead and political leaders sharpen up their vision.
Endocrinology

The Ultimate Brow Lift: HDAC8 In The Epigenetic Control Of Skull Morhpgenesis

In the July 15th cover story of G and D, a research team led by Dr. Eric Olson at the UT Southwestern Medical Center at Dallas reports that the class I histone deacetylase 8 (HDAC8) enzyme regulates gene expression in the developing vertebrate skull. HDAC8 overexpression is associated with a poor prognosis in human neuroblastoma patients. "As there are many different isoforms of histone deacetylases, it is crucial to understand the specific function of each -- with the putative goal of targeting a specific subset for a specific disease process," explains Dr. Mike Haberland, lead author on the study. Dr. Olson"s team explored the role of HDAC8 in verterbrate skull morphogenesis, using a strain of knockout mice specifically lacking HDAC8 in cranial neural crest cells. Neural crest cells (NCCs) are a specialized group of embryonic cells that - among other things - have evolved to generate the unsegmented vertebrate head, which has allowed vertebrates to transform from a passive, filter feeding animal into an active predator with paired eyes, an enlarged brain and protective skull, and ultimately, teeth and jaws. The researchers found that HDAC8 deletion causes a deficiency of cranial NCCs, resulting in skull dysmorphism and instability, and perinatal death due to brain trauma. Microarray profiling revealed that HDAC8 represses multiple homeobox transcription factors that are active in the cranial NCC population, and function to pattern the frontal skull. Thus, HDAC8 has a crucial role in the epigenetic control of vertebrate skull development. Heather Cosel-Pieper Cold Spring Harbor Laboratory


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