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Gene Therapy Technique Thwarts Cancer By Cutting Off Tumor Blood Supply
University of Florida researchers have come up with a new gene therapy method to disrupt cancer growth by using a synthetic protein to induce blood clotting that cuts off a tumor"s blood and nutrient supply.
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A Simpler Definition For Major Depressive Disorder
Researchers from Rhode Island Hospital"s department of psychiatry propose that the definition for major depressive disorder (MDD) should be shortened to include only the mood and cognitive symptoms that have been part of the definition in the Diagnostic and Statistical Manual of Mental Disorders (DSM) for the past 35 years. Their recommendation would exclude those symptoms that are currently part of the definition that may be associated with medical illness rather than depression. The proposal is based on a study that appears in the July 23 online first edition of the journal Psychological Medicine.
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Finding The Right Connection After Spinal Cord Injury
In a major step in spinal cord injury research, scientists at the University of California, San Diego School of Medicine have demonstrated that regenerating axons can be guided to their correct targets and re-form connections after spinal cord injury. Their findings were published in the advance online edition of the journal Nature Neuroscience on August 2.
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UPMC Cardiovascular Institute Recruiting For Severe Coronary Heart Disease Study

The UPMC Cardiovascular Institute currently is enrolling participants for a Phase 2 clinical trial to examine whether administering a naturally occurring protein improves blood supply to the cardiac muscle in patients with severe coronary artery disease. The study, known as Angiogenesis for the Treatment of Coronary Heart Disease (ACORD), is a randomized, double-blind, placebo-controlled trial that compares the use of a protein at three dose levels with a placebo. The therapy is delivered to the heart muscle by threading a catheter through a small incision in the upper leg. "Other studies have hinted that this approach can reduce the severity of angina in patients who have exhausted all other treatment options," said Oscar Marroquin, M.D., director of the UPMC Center for Interventional Cardiology Research and principal investigator of the study. "It appears the protein, called FGF-1, is able to stimulate the growth of new blood vessels to get around existing blockages and improve blood flow to the heart." This trial is designed to see whether FGF-1 can help patients and, if so, how much should be given. To be eligible for the study, patients must have a history of angina or chronic chest pain that persists despite optimal drug therapy. The ACORD trial is expected to enroll 120 patients, including 10 from the UPMC Cardiovascular Institute, at 30 medical centers throughout the United States. University of Pittsburgh


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