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Ceregene Presents Additional Clinical Data From Phase 2 Trial Of CERE-120 For Parkinson's Disease
Ceregene, Inc. reported additional clinical data from a double-blind, controlled Phase 2 trial of CERE-120 in 58 patients with advanced Parkinson"s disease. CERE-120 uses AAV-based gene therapy to deliver the neurotrophic factor, neurturin, to Parkinson"s disease patients in order to restore the function and protect degenerating nigrostriatal neurons. The company previously announced that the Phase 2 trial did not meet its primary endpoint of improvement in the Unified Parkinson"s Disease Rating Scale (UPDRS) motor off score at 12 months of follow-up, although several secondary endpoints suggested a modest clinical benefit.
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Meda: Onsolis Receives FDA Approval
The U.S. Food and Drug Administration (FDA) has approved Onsolis (fentanyl buccal soluble film). This new and patented product is indicated for the management of breakthrough pain in cancer patients who are already receiving and who are tolerant to opioid therapy for their underlying persistent cancer pain. Onsolis uses a unique delivery system designed to give rapid and reliable delivery of fentanyl. The product consists of a small dissolvable disc for application of fentanyl to the buccal (inner lining of cheek) membranes. The product is unique and offers an important step to a better pain treatment of cancer patients.
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Swine Flu Daily Update Issued At: 11am Monday 6 July 2009, Wales
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Victorian Invention A Watchful Approach To Parkinson's

Victorian researchers have developed a wristwatch that continuously monitors the health status of people with Parkinson"s disease to help doctors manage their treatment, Victorian Minister for Innovation Gavin Jennings said today. The wristwatch, which is still at the prototype stage, was introduced onto the world market by Mr Jennings at BIO2009 in Atlanta, USA. It is designed to assist doctors treating people with Parkinson"s disease by recording their symptoms throughout the day and in the longer term will assist researchers in the development of new drugs for the disease. "The Brumby Government is taking action to promote innovative projects in Victoria and this is an excellent example of how Victorian scientists are moving from basic research into developing products that will clearly benefit patients and their families," Mr Jennings said. "The right dosage and correct timing of dosing has an enormous impact on the wellbeing of a person with Parkinson"s disease. Currently neurologists can only check dosage and timing by observing the patient during consultations, which may be at 6-8 week intervals. "What this clever device does is provide the physician with an objective measurement of how a patient"s symptoms have changed over time. It is the first of its kind and will provide physicians with information about the effectiveness of medications and guide them in adjusting the timing of medications." The wristwatch (patent pending) has been developed by a team led by Professor Mal Horne and Dr Rob Griffiths at the Florey Neuroscience Institutes in Melbourne. Mr Jennings said the device would assist in the development of drugs for Parkinson"s disease which was hampered by an inability to accurately assess whether the treatment is effective. The next stage of development for the wristwatch is being funded by Melbourne"s Medical Research Commercialisation Fund. The MRCF is a collaborative venture fund established with support from the Victorian and NSW Governments. Dr Chris Nave, Principal Executive of the MRCF, said the fund had invested an initial $490,000 in Global Kinetics Corporation, a spinout company from the Melbourne-based Florey Neuroscience Institutes to enable researchers to further refine the watch and complete pivotal clinical trials. "We are very pleased to be involved in taking this simple, yet effective, device to its next stage," said Mr Nave. Parkinson"s disease is a degenerative disorder of the brain that often affects body movements and speech. About 80,000 people are living with Parkinson"s in Australia with one in five people with Parkinson"s diagnosed before the age of 50. In the USA, the disease affects up to two percent of the population and is the most common neurodegenerative movement disorder. The Premier of Victoria. Australia


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